He began his professional career as a welder before working on an oil rig for Doyon Drilling. He eventually quit to pursue an acting career in Los Angeles. Sensmeier began work as a professional model before entering into acting. His first feature film was an indie thriller called False Memory Syndrome, which has yet to be released. He was cast in a leading role in the movie The Magnificent Seven, alongside big names such as Denzel Washington, Chris Pratt, Ethan Hawke and Vincent D’Onofrio.
As of 2016, Sensmeier is in a relationship with Navajo Native American vocalist Kahara Hodges. He is a member of the Native Wellness Institute, a youth advocacy, and is proud of his Alaska Native heritage.